Free creatine available to the creatine phosphate energy shuttle in isolated rat atria.
نویسندگان
چکیده
منابع مشابه
Creatine-creatine phosphate shuttle modeled as two-compartment system at different levels of creatine kinase activity.
In order to characterize ADP-ATP and creatine-creatine phosphate (Cr-CrP) shuttles a minimal mathematical model with two compartments and cyclic turnover of matter was designed. The 'mitochondrial' compartment contained 'ATP-synthase' and 'mitochondrial creatine kinase' (mitCK). The 'cytoplasmic' compartment consisted of 'ATPase', 'cytoplasmic creatine kinase' (cytCK) and an 'ADP-binding struct...
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Earlier studies showed that there is significant creatine kinase activity in the epiphyseal growth cartilage, and there is stage-specific isoform expression. To further explore the role of this enzyme in cartilage development, we disrupted the creatine kinase creatine phosphate (CK-CP) circuit using the creatine analogue, cyclocreatine. We found that while cyclocreatine decreased creatine kinas...
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Creatine phosphate serves as a reuseable high energy phosphate reservoir in skeletal and cardiac muscle and in the brain. These stores of creatine phosphate are thought to rephosphorylate the ATP hydrolyzed during cellular work (see 1 and 2 for review). Studies in our laboratory (3) have shown that mononuclear phagocytes obtained from the peritoneal cavities of mice also contain large stores of...
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The precursors, mechanism, and site of creatine formation are still uncertain, even though they have received the attention of investigators for many years. An examination of the results on creatine formation summarized in Hunter’s monograph (1928) shows the many contradictions in this field. In the 10 years which have elapsed since the publication of this work, few experiments in vivo have bee...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1988
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.85.20.7476